Pulsatile reperfusion does not modify global myocardial ischemic injury
نویسندگان
چکیده
منابع مشابه
Does cool reperfusion limit myocardial infarction injury?
The investigator team is to be congratulated for successfully surmounting a formidable implementation challenge. Within 30 minutes, they were able to rapidly cool patient body temperatures to an average less than the target temperature of 35°C without allowing the induction of cooling to interfere with or prolong the door-to-balloon time for percutaneous coronary intervention. To put this 30-mi...
متن کاملThe effect of asafoetida essential oil on myocardial ischemic-reperfusion injury in isolated rat hearts
Objective: Previous studies reported that asafetida from Ferula assa-foetida Linn. species and its essential oil (AEO) have antioxidant effects. In the present study, the effect of AEO was evaluated on ischemic-reperfusion injury in isolated rat hearts. Materials and Methods: Forty-eight male Wistar rats were divided into 6 groups: 1) control group, 2) vehicle group, 3-5) AEO groups and, 6) car...
متن کاملSystemic Dosing of Thymosin Beta 4 before and after Ischemia Does Not Attenuate Global Myocardial Ischemia-Reperfusion Injury in Pigs
The use of cardiopulmonary bypass (CPB) and aortic cross-clamping causes myocardial ischemia-reperfusion injury (I-RI) and can lead to reduced postoperative cardiac function. We investigated whether this injury could be attenuated by thymosin beta 4 (TB4), a peptide which has showed cardioprotective effects. Pigs received either TB4 or vehicle and underwent CPB and aortic cross-clamping for 60 ...
متن کاملIschemic and Reperfusion Injury
The study 1 published in this issue of Circulation Research showing that a null mutation of NHE-1 improves the tolerance of the heart to ischemia and reperfusion (I/R) is an important contribution for the following reasons: (1) In the animals with null mutation, contracture during the ischemic period was less and ATP levels were preserved compared with wild-type animals. This observation, on th...
متن کاملEplerenone does not limit ischemia-reperfusion injury in human myocardial tissue.
Article history: Received 24 March 2016 Accepted 16 April 2016 Available online 22 April 2016 Background: Despite rapid reperfusion, mortality and morbidity in patients with an acute myocardial infarction remain significant. Therefore, novel pharmacological strategies to further limit ischemia–reperfusion (IR) injury are warranted. In animal models of myocardial infarction, mineralocorticoid re...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Thoracic and Cardiovascular Surgery
سال: 1982
ISSN: 0022-5223
DOI: 10.1016/s0022-5223(19)39012-9